FIG. 2.

DNA sequence conservation in the Qp promoter region. The Qp promoter region of the B95-8 EBV genome sequence (coordinates 61,886 to 62,498) (4) is aligned with the DNA sequences of the homologous regions of the BaLCV and RhLCV genomes and represents nucleotides −537 to +76 relative to the major transcription start site (+1) within the EBV Qp (45, 63). Known and predicted promoter-regulatory elements (see text) are boxed and include those for the lytic cycle-specific EBNA-1 promoter Fp (CAAT, LR-1, TATA, and Sp1) (8, 56) as well as for Qp (QRE-1, QRE-2, E2F, and EBNA-1) (42–44, 57, 60, 61, 68). Sites of transcription initiation are denoted by bent arrows. Differences in the BaLCV and RhLCV sequences relative to that of EBV are indicated; dots and dashes represent identical and deleted nucleotides, respectively.