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. 2023 Aug 8;14:1172892. doi: 10.3389/fimmu.2023.1172892

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Copyright © 2023 Ying, Zhang, Wang, Liu, Yu, Wang, Chen, Zhou and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Syndecan-1 (SDC1) is a prognosis biomarker of children with septic shock. (A) ELISA to detect the levels of SDC1and IL-6 in plasma from 28 children with sepsis within 24 hours of PICU admission (day 1). (B) Correlation between levels of IL-6 and SDC1. (C) Changes of levels of SDC1 and heparan sulfate in plasma from day 1 to day 3. (D) ROC curve analysis of SDC1 expression on day 1 between survival group and non-survival group. Bars and error bars represent the mean ± SEM; *p < 0.05, **p < 0.01.