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. 2023 Aug 8;14:1172892. doi: 10.3389/fimmu.2023.1172892

Figure 5.

Figure 5

Inhibition of SDC1 shedding by Sulodexide improved lung injury and survival in septic mice. (A) Pattern diagram of the septic mouse model. Mice were pretreated with sulodexide (40 mg/kg) for 2 h before LPS injection or CLP procedure and those mice were observed for 12 h following LPS and 24 h following CLP before euthanasia. (B, D) ELISA to detect the plasma levels of SDC1 and IL-6 in the LPS (20 mg/kg)-challenged (B) and CLP-induced (D) septic model. (C, E) Survival curves after sulodexide administration to LPS (30 mg/kg)-challenged (C) and CLP-induced (E) mice, n=10/group/experiment. (F) Representative lung tissue sections stained with HE at ×100 (D) in LPS-induced sepsis model. (G) Lung tissue W/D weight ratio in LPS- induced sepsis model. (H) Representative immunofluorescence images of SDC1 in lungs, scale bar = 200 μm. (I) Densitometry of SDC1 immunofluorescence in lungs. Data are expressed as means ± SEM; *p < 0.05.