Table 3.
Comparison of symptoms included in CoMiSS between the CMA confirmed and negative groups at T0.
| Crying | Regurgitation | Stool | Skin | Respiratory | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cow milk allergy | p | Cow milk allergy | p | Cow milk allergy | p | Cow milk allergy | p | Cow milk allergy | p | ||||||
| Group | Negative N (%) | Confirmed N (%) | Negative N (%) | Confirmed N (%) | Negative N (%) | Confirmed N (%) | Negative N (%) | Confirmed N (%) | Negative N (%) | Confirmed N (%) | |||||
| Yes | 13 (81.25%) | 77 (91.67%) | 0.204 NS | 12 (75.00%) | 63 (75.00%) | 1.000 NS | 12 (75.00%) | 79 (94.05%) | 0.015* | 6 (37.50%) | 54 (64.29%) | 0.046* | 7 (43.75%) | 42 (50.00%) | 0.647 NS |
| No | 3 (18.75%) | 7 (8.33%) | 4 (25.00%) | 21 (25.00%) | 4 (25.00%) | 5 (5.95%) | 10 (62.50%) | 30 (35.71%) | 9 (56.25%) | 42 (50.00%) | |||||
| Total score | 16 (100.00%) | 84 (100.00%) | 16 (100.00%) | 84 (100.00%) | 16 (100.00%) | 84 (100.00%) | 16 (100.00%) | 84 (100.00%) | 16 (100.00%) | 84 (100.00%) | |||||
| 0 | 3 (18.75%) | 7 (8.33%) | 0.204 NS | 4 (25.00%) | 21 (25.00%) | 1.00 NS | 4 (25.00%) | 5 (5.95%) | 0.015* | 10 (62.50%) | 30 (35.71%) | 0.046* | 9 (56.25%) | 42 (50.00%) | 0.646 NS |
| 1 | 3 (18.75%) | 7 (8.33%) | 0.204 NS | 1 (6.25%) | 4 (4.76%) | 0.802 NS | NA | NA | NA | 0 (0.00%) | 3 (3.57%) | 0.441 NS | 2 (12.50%) | 15 (17.86%) | 0.603 NS |
| 2 | 1 (6.25%) | 3 (3.57%) | 0.617 NS | 1 (6.25%) | 5 (5.95%) | 0.960 NS | 1 (6.25%) | 4 (4.76%) | 0.803 NS | 4 (25.00%) | 21 (25.00%) | 1.00 NS | 3 (18.75%) | 12 (14.29%) | 0.646 NS |
| 3 | 0 (0.00%) | 5 (5.96%) | 0.317 NS | 1 (6.25%) | 3 (3.57%) | 0.617 NS | NA | NA | NA | 2 (12.50%) | 14 (16.67%) | 0.674 NS | 2 (12.50%) | 15 (17.86%) | 0.603 NS |
| 4 | 3 (18.75%) | 3 (3.57%) | 0.019* | 1 (6.25%) | 6 (7.14%) | 0.896 NS | 4 (25.00%) | 19 (22.62%) | 0.834 NS | 0 (0.00%) | 3 (3.57%) | 0.441 NS | NA | NA | NA |
| 5 | 0 (0.00%) | 0 (0.00%) | NA | 0 (0.00%) | 8 (9.52%) | 0.197 NS | NA | NA | NA | 0 (0.00%) | 4 (4.76%) | 0.373 NS | NA | NA | NA |
| 6 | 6 (37.50%) | 59 (70.24%) | 0.012* | 8 (50.00%) | 37 (44.05%) | 0.660 NS | 7 (43.75%) | 56 (66.67%) | 0.081 NS | 0 (0.00%) | 9 (10.71%) | 0.0171 NS | NA | NA | NA |
N number of infants, YES the symptom was reported, * statistically significant, NS non significant.
NA not applicable because CoMiSS score does not include this point score for this item in the stool or in respiratory symptoms.
Stool change items include diarrhea, soft stool, normal stool, and constipation.
Score 4 in stool changes refers to both constipation (2 cases in negative CMA group and 7 cases in confirmed CMA group) and diarrhea (2 cases in the negative CMA group, 12 cases in the confirmed CMA group).