Table 4.

CoMiSS score initially (T0) and after 4 weeks of CMFD (T1) in both the groups.

		Negative CMA (n = 16)	Confirmed CMA (n = 84)	Test of significance, p value
Total CoMiSS Score T0
Median [min–max]		12.00 [6.00–22.00]	17.00 [2.00–26.00]	0.006*
Mean ± SD		12.44 ± 5.01	16.39 ± 5.13
Crying: median [IQR]		4.00 [5.00]	6.00 [3.00]	0.016*
Regurgitation: median [IQR]		5.00 [5.50]	5.00 [1.00]	0.905 NS
Stool: median [IQR]		4.00 [5.00]	6.00 [2.00]	0.038*
Skin: median [IQR]		0.00 [2.00]	2.00 [6.00]	0.026*
Respiratory: median [IQR]		0.00 [2.00]	0.50 [2.00]	0.669 NS
Total CoMiSS Score T1
Median [min–max]		6.50 [0.00–15.00]	1.50 [0.00–10.00]	0.001*
Mean ± SD		7.19 ± 5.55	2.07 ± 2.24
Crying: median [IQR]		1.50 [4.00]	0.00 [2.00]	0.040*
Regurgitation: median [IQR]		1.50 [3.00]	0.00 [0.00]	<0.0001*
Stool: median [IQR]]		0.00 [5.00]	0.00 [0.00]	0.002*
Skin: median [IQR]		0.00 [1.50]	0.00 [0.00]	0.037*
Respiratory: median [IQR]		0.00 [0.00]	0.00 [1.00]	0.598 NS
Total CoMiSS Score percentage change
Median [IQR]		−36.11 [−78.81]	−91.41 [−18.35]	<0.0001*
Mean ± SD		−44.33 ± 40.47	−87.22 ± 13.97
Percentage of patients improved after CMFD (n, %)
Crying	78/90 (86.67%)	5/13 (38.46%)	73/77 (94.81%)	<0.0001*
Regurgitation	69/75 (92.00%)	8/12 (66.67%)	61/63 (96.83%)	0.0004*
Stool	82/91 (90.11%)	6/12 (50.00%)	76/79 (96.20%)	<0.0001*
Skin	54/60 (90.00%)	2/6 (33.33%)	52/54 (96.30%)	<0.0001*
Respiratory	34/49 (69.39%)	5/7 (71.43%)	29/42 (69.05%)	0.429 NS
Total CoMiSS Score percentage change
>50% reduction in total score		8 (50.00%)	82 (97.62%)	<0.0001*

IQR interquartile range, * statistically significant, NS non significant.