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. 2023 Mar 1;94(3):1018–1025. doi: 10.1038/s41390-023-02510-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — BSID-III 10 a cognitive, b language, and c motor scores at 2 years of age in relation to lactate/NAA and NAA/Cr ratio quartiles in the thalamus among survivors of moderate to severe HIE. Mean change (95% confidence interval) in BSID-III score per 0.1 unit increase in lactate/NAA ratio, adjusted for site, treatment, and HIE severity: cognitive score: -0.7 (-1.1, -0.4); language score -0.8 (-1.3, -0.3); motor score -1.0 (-1.4, -0.5). Mean change (95% confidence interval) in BSID-III score per 0.1 unit increase in NAA/Cr ratio, adjusted for site, treatment, and HIE severity: cognitive score: 3.6 (1.9,5.3); language score 4.7 (2.6,6.8); motor score 4.4 (2.5,6.3).