Table 1.
Summary of clinical indices at T0 and T1
| T0 Index | T1 Interval | Wilcoxon Rank | ||||||
|---|---|---|---|---|---|---|---|---|
| Median | IQR Low | IQR High | Median | IQR Low | IQR High | P-value | Z | |
| Clinical biochemistry | ||||||||
| White cell count (× 109/L) | 7.6 | 6.2 | 11.2 | 7.6 | 6.3 | 10.0 | 0.594 | |
| C-reactive protein (mg/L) | 8.8 | 2.2 | 19.6 | 5.0 | 2.9 | 11.3 | 0.026 | − 2.22 |
| Albumin (g/L) | 41.0 | 36.0 | 42.0 | 40.0 | 38.0 | 42.0 | 0.282 | |
| Creatinine (μmol/L) | 83.0 | 67.0 | 94.3 | 89.0 | 77.0 | 99.0 | 0.008 | − 2.67 |
| Urea (mmol/L) | 6.6 | 4.8 | 7.7 | 6.6 | 5.5 | 8.5 | 0.290 | |
| Creatinine kinase (U/L) | 114.0 | 59.0 | 263.0 | 96.0 | 65.3 | 160.5 | 0.009 | − 2.62 |
| Alanine transaminase (ALT) (U/L) | 25.6 | 17.4 | 31.0 | 28.0 | 21.4 | 33.1 | 0.214 | |
| Spirometry | ||||||||
| FVC% Predicted | 83.7 | 73.5 | 105.9 | 78.7 | 66.6 | 93.4 | 0.002 | − 3.12 |
| DLCO% Predicted | 63.4 | 46.0 | 83.5 | 60.6 | 42.3 | 76.5 | 0.008 | − 2.66 |
| Morphometrics | ||||||||
| Muscle | ||||||||
| Pectoralis CSA in cm2 | 39.8 | 28.8 | 52.2 | 40.7 | 30.5 | 50.9 | 0.491 | |
| Pectoralis HU | 35.3 | 29.4 | 40.9 | 31.0 | 27.4 | 38.3 | 0.035 | − 2.11 |
| Pectoralis Index (CSA/m2) | 14.3 | 11.0 | 16.7 | 14.4 | 11.7 | 18.8 | 0.453 | |
| Erector spinae CSA in cm2 | 35.2 | 28.7 | 41.0 | 39.5 | 31.3 | 43.3 | 0.098 | |
| Erector spinae HU | 38.0 | 32.2 | 46.1 | 33.7 | 27.4 | 40.4 | 0.023 | − 2.27 |
| Erector spinae index (CSA/m2) | 12.4 | 10.5 | 14.2 | 13.6 | 11.8 | 15.7 | 0.094 | |
| Fat | ||||||||
| Subcutaneous CSA T12 in cm2 | 103.9 | 87.0 | 205.8 | 136.1 | 93.9 | 195.9 | 0.009 | − 2.60 |
| Subcutaneous Index (CSA/m2) | 36.9 | 29.5 | 77.9 | 44.7 | 32.3 | 76.2 | 0.009 | − 2.62 |
| Visceral CSA T12 in cm2 | 110.4 | 61.7 | 180.6 | 128.1 | 69.3 | 187.6 | 0.178 | |
| Visceral Index (CSA/m2) | 43.7 | 22.7 | 60.1 | 44.4 | 25.6 | 62.8 | 0.237 | |
| Visceral CSA LMCO in cm2 | 23.2 | 19.7 | 33.8 | 27.4 | 19.2 | 37.2 | 0.147 | |
| Visceral: Subcutaneous Ratio | 0.9 | 0.5 | 1.7 | 0.8 | 0.6 | 1.8 | 0.926 | |
Characteristics of patients with IIM measured at diagnosis before treatment (T = 0) and after a variable period of treatment (T = 1). Blood parameters, lung function and morphometric data including muscle cross sectional area and density are included. Data are expressed as medians with interquartile ranges
IQR interquartile range, FVC% predicted forced vital capacity expressed as percent predicted, DLCO% predicted single breath carbon monoxide gas transfer factor expressed as percent predicted, Pectoralis CSA pectoralis muscle cross sectional area expressed as centimetres squared, Erectors spinae CSA erector spinae muscle cross sectional area expressed as centimetres, Pectoralis HU pectoralis muscle density expressed as Hounsfield units, Erector spinae HU erector spinae muscle density expressed as Hounsfield units, Pectoralis index pectoralis muscle cross-sectional area in centimetres squared divided by height squared in metres, Erector spinae index erector spinae muscle cross-sectional area in centimetres squared divided by height squared in metres