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. 2023 Jul 14;12(5):1491–1515. doi: 10.1007/s40120-023-00518-0
Ofatumumab is the first fully human anti-CD20 monoclonal antibody to be approved for the treatment of relapsing multiple sclerosis.
Rapid and sustained near-complete B-cell depletion can be achieved with ofatumumab treatment and maintained with monthly subcutaneous doses of 20 mg/0.4 ml.
The tolerability profile and at-home self-administration of ofatumumab enables patients to be compliant with and persistent on therapy over time.
The benefit–risk profile of ofatumumab supports its early initiation in the overall RMS population in order to maximize its long-term treatment benefits.