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. 2023 Jun 30;14(4):355–360. doi: 10.1007/s12687-023-00657-9

Table 2.

Selected red cell indices depicted as mean, SD (median) in beta thalassaemia trait and normal AA phenotypes with significance of differences

Phenotype (n) Hb (g/dL) RBC (×1012/L) MCV (fL) p value deviation from HbAA
Hb RBC MCV
Males
 HbAA 5720 14.5, 1.2 (14.5) 5.1, 0.4 (5.1) 84.0, 5.7 (85) - - -
 -29 A>G 19 13.6, 0.8 (13.5) 5.8, 0.5 (5.7) 70.8, 3.7 (70) 0.12 <0.001 <0.001
 -88 C>T 26 13.6, 1.1 (14.0) 5.8, 0.5 (5.7) 71.5, 4.0 (71) 0.017 <0.001 <0.001
 -90 C>T 5 13.6, 1.5 (14.1) 6.0, 0.4 (5.7) 71.2, 8.1 (70) 0.8 0.002 0.0024
 Poly A T>C 3 13.8, 0.9 (14.1) 6.0, 0.6 (6.1) 71.3, 0.3 (70) 0.9 0.052 0.005
 IVSII-781 C>G 2 14.9, 1.5 (14.9) 5.8, 0.4 (5.8) 79.5, 3.6 (80) 1.0 0.6 0.13
 IVSII-849 A>G 8 12.7, 1.5 (12.6) 6.2, 0.4 (6.3) 62.7, 3.5 (63) 0.003 <0.001 <0.001
Females
 HbAA 7219 12.5, 1.2 (12.6) 4.5, 0.4 (4.5) 83.0, 7.1 (84) - - -
 -29 A>G 16 12.0, 0.6 (12.1) 5.2, 0.4 (5.0) 71.4, 3.0 (72) 0.014 <0.001 <0.001
 -88 C>T 32 12.2, 0.8 (12.3) 5.0, 0.4 (5.0) 73.7, 3.9 (74) 0.056 <0.001 <0.001
 -90 C>T 6 12.2, 1.0 (12.5) 5.5, 0.7 (5.5) 69.9, 3.2 (69) 0.4 <0.001 <0.001
 Poly A T>C 2 12.1, 0.8 (12.1) 5.2, 0.0 (5.2) 72.8, 5.9 (73) 0.4 0.33 0.051
 IVSII-781 C>G 3 12.3, 0.5 (12.2) 4.7, 0.3 (4.7) 82.1, 2.3 (81) 0.5 0.9 0.5
 IVSII-849 A>G 2 10.9, 0.1 (10.9) 5.4, 0.3 (5.4) 64.0, 0.0 (64) 0.04 0.1 0.018

Hb total haemoglobin, RBC red cell count, MCV mean cell volume