Table 3.
The oxidative stress markers measurement in PTC patients with angioinvasion and metastasis (study group) versus PTC patients without angioinvasion and metastasis (reference group).
| Parameter | Unit | Study group (n = 56) | Reference group (n = 24) | P-value |
|---|---|---|---|---|
| Median (range) | Median (range) | |||
| TOC | umol/l | 444 | 451 | 0.826 |
| (223–1009) | (123–882) | |||
| TAC | umol/l | 225 | 276 | 0.036 |
| (190–324) | (171–373) | |||
| MDA | µM | 174 | 97 | 0.049 |
| (31–650) | (3–373) | |||
| DNA/RNA OSDP | pg/mL | 611 | 510 | 0.008 |
| (405–750) | (310–684) | |||
| IL-6 | pg/mL | 1.8 | 1.56 | 0.266 |
| (0.9–4.4) | (0.2–5.7) | |||
| SIRT1 | ng/mL | 4.5 | 4.0 | 0.124 |
| (3.5–5.6) | (3.1–9.3) | |||
| SIRT3 | ng/mL | 4.5 | 5.8 | 0.011 |
| (1.7–7.6) | (2.9–34.3) | |||
| NF-κB | pg/mL | 196 | 157 | 0.537 |
| (133–486) | (127–674) | |||
| FOXO | pg/mL | 41 | 59 | 0.547 |
| (27–289) | (26–413) | |||
| DNA methylation | ng/ml | 91 | 91 | 0.947 |
| (66–108) | (79–110) | |||
| PRKAA1 | pg/mL | 86 | 78 | 0.179 |
| (35–200) | (14–247) | |||
| PGC1α | pg/mL | 57 | 78 | 0.849 |
| (15–513) | (14–248) | |||
| p53 | pg/mL | 203 | 207 | 0.675 |
| (101–2619) | (110–3163) |
Bold indicates that the values given are statistically significant.
IL-6, interleukin 6; FOXO, Forkhead box O family member proteins; NF-κB, nuclear factor kappa B; MDA, malondialdehyde; p53, protein 53; SIRT1, Sirtuin 1; SIRT3, Sirtuin 3; TAC, total antioxidant capacity; TOC, total oxidative capacity; PRKAA1 5′-AMP-activated protein kinase catalytic subunit alpha-1; PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; MDA, malondialdehyde, DNA/RNA DNA/RNA oxidative stress damage products.