Table 2.
Results of cytotoxic activity screened against HepG2 cell line as IC50 in μM.
| Compound No. | R1 | R2 | IC50 (μM)* |
|---|---|---|---|
| 10a | Cl | H | 4.60 ± 0.28 |
| 10b | Cl | 4-CH3 | 50.83 ± 3.16 |
| 10c | Cl | 3-CH3 | 4.14 ± 0.25 |
| 10d | Cl | 2-CH3 | 1.07 ± 0.06 |
| 10e | Cl | 4-F | 0.88 ± 0.05 |
| 10f | Cl | 3-CF3 | 62.02 ± 3.87 |
| 10g | Cl | 4-CN | 43.15 ± 2.59 |
| 10h | Cl | 4,5-thiazolyl | 14.94 ± 0.52 |
| 10i | Cl | 4-isopropyl | 1.60 ± 0.17 |
| 10j | F | H | 41.91 ± 2.52 |
| 10k | F | 4-CH3 | 34.21 ± 2.06 |
| 10l | F | 3-CH3 | 14.18 ± 0.82 |
| 10m | F | 2-CH3 | 13.01 ± 0.75 |
| 10n | F | 4-F | 2.88 ± 0.14 |
| 10o | F | 3-CF3 | 2.76 ± 0.1 |
| 10p | F | 4-isopropyl | 8.14 ± 0.47 |
| Sorafenib | – | – | 8.38 ± 0.5 |
*IC50 values are the average of 3 independent runs ± SE.