Table 2.

Disease-related mitochondrial omics sequencing data summary

Organ	Disease	Experimental method	Reference
Nervous system	Mitochondrial encephalomyopathy	mtDNA sequencing	170,171
	Cerebral metabolic abnormalities	mtDNA sequencing	172
	Parkinson’s disease	mtDNA sequencing. Proteome	174,175
	Frontotemporal lobar degeneration	mtDNA sequencing	401
	Neurodegeneration	Proteome	130
	Alzheimer’s disease	Proteome. Interatomic analysis	195,402
	Amyotrophic lateral sclerosis	Interatomic analysis	403
	Spinal muscular atrophy	Proteome	176
	Neurodegenerative disease	Proteome	177
Cardiovascular system	Heart failure	Acetylproteome. Proteome	135,216,217,404
	Myopathy and progressive external ophthalmoplegia	Genome sequencing	405
	Mitochondrial cardiomyopathy	Genome sequencing	406
	Leigh syndrome	mtDNA sequencing	407
	Cardiovascular diseases	mtDNA sequencing	215
	Cardiac hypertrophy and heart failure	Proteome	408
	Atrial fibrillation	Proteome	409
	Proteome comparison of human hearts	Proteome	410
Liver	Hepatocellular carcinoma	mtDNA sequencing	50,230
	Nonalcoholic fatty liver disease	Proteome	232,233,411,412
	Aging and the development of liver diseases	Proteome	413
	Cholangiocarcinoma	Proteome	414
	Liver fibrosis	Proteome	415
Skeletal muscle	Aging	mtDNA sequencing	273
	Myopathy	mtDNA sequencing	271
	Obesity and T2D, muscle IR	Proteome	270,274,277–279,416
	Aging	Proteome	267,269,280,417
	Myosteatosis	Proteome	283,418
Adipose	Aging	Proteome	291,292,299
	Diabetes	Proteome	289,290,298
Immune cell	Immune cells	mtDNA sequencing	315
	Innate immune-monocyte-septic shock	Proteome	316
	Innate immune-macrophage-bacterial resistance	Proteome	319
	Innate immune-natural killer cells-	Proteome	419
	adaptive immunity-T-cells	Proteome	31,320,321
Cancer	Kidney, colorectal and thyroid cancers	mtDNA sequencing	420
	Nasopharyngeal carcinoma	Proteome	333
	Human ovarian cancer	Proteome	334,335