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. 2023 Aug 23;8:312. doi: 10.1038/s41392-023-01545-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A20 regulated STC1 expression. a A20 expression level in A20-knockout (KO) and A20-KO-rescue (RE) cells. RNA-sequencing was conducted to investigate the gene profiles from HCT116 cells after manipulation of A20 expression (WT: wild type; KO: A20-knockout; RE: A20-rescue). b The Venn diagram of the genes altered by A20 with the p-value < 0.05. c Heat map of 13 genes (n = 3 samples of each group). Blue, downregulation; red, upregulation. d The expression of 10 genes were detected by q-PCR, n = 4. e The expression of STC detected by immunoblotting. f Representative immunohistochemical staining images of different intensity of STC1 expression in tumor specimens. g Representative images of STC1 and A20 staining in tumor specimens from CRC patients. h Statistical analysis of STC1 expression in CRC tissues with high or low A20 expression, n = 118. i Correlation analysis of STC1 and A20 expression in CRC tissues, n = 118. j Immunoblotting analysis of A20 and STC1 expression in CRC cell lines (n = 8). k, l Correlation analysis of A20 and STC1 expression in CRC cell lines and TCGA database. m, n Survival analysis of CRC patients (H-score≤6, low; >6, high). o Survival analysis of CRC patients in TCGA dataset