Table 2.
Comparison of MRI parameters and cognitive function with and without CI
| Non-CI group (N = 20) | CI group (N = 31) | T/Z | p value | |
|---|---|---|---|---|
| MMSE score | 28.00 (28.00–29.00) | 24.00 (21.00–25.00) | 6.029 | < 0.001 |
| VFT score | 19.37 ± 4.06 | 13.00 ± 5.63 | 4.172 | < 0.001 |
| BNT score | 23.79 ± 3.47 | 18.15 ± 5.28 | 4.075 | < 0.001 |
| Total Fazekas scorea | 4.00 (3.00–4.50) | 4.00 (4.00–5.00) | 1.709 | 0.087 |
| Total WMH volume (cm3) | 5.22 (1.22–12.94) | 8.66 (3.79–13.97) | 1.601 | 0.109 |
| PS in periventricular WMH | 1.00 × 10−3 (0.68–1.78 × 10−3) | 1.89 × 10−3 (0.95–7.87 × 10−3) | 2.141 | 0.032 |
| PS in deep WMH | 0.74 × 10−3 (0.38–1.84 × 10−3) | 1.27 × 10−3 (0.69–13.91 × 10−3) | 2.026 | 0.043 |
| GMV (cm3) | 661.40 ± 19.93 | 605.10 ± 12.66 | 2.509 | 0.015 |
| ICV (cm3) | 1572.26 ± 33.70 | 1475.67 ± 22.63 | 2.474 | 0.017 |
| GMV/ICV | 0.42 ± 0.03 | 0.41 ± 0.03 | 1.101 | 0.276 |
| WMH volume/ICV | 3.21 × 10−3 (0.75–8.34 × 10−3) | 5.77 × 10−3 (2.35–8.27 × 10−3) | 1.775 | 0.076 |
Data are expressed as the median (interquartile range) or mean ± standard deviation according to the normality of their distribution
WMH white matter hyperintensities, MMSE Mini-Mental State Examination, CI cognitive impairment, VFT verbal fluency test, BNT Boston Naming Test, ICV intracranial volume, GMV grey matter volume, PS permeability–surface area product (unit min−1)
aFazekas score: The severity of periventricular (adjacent to the lateral ventricles) and deep (not adjacent to the lateral ventricles) WMH is scored visually to yield the Fazekas total score (sum of the periventricular and deep WMH scores)