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. 2023 Jul 25;12(5):1745–1758. doi: 10.1007/s40120-023-00527-z
Why carry out this study?
In patients with WMH of CSVD, WMH burden is related to cognition. However, a similar WMH burden may have varied cognitive outcomes.
This study aimed to evaluate whether the permeability of the blood–brain barrier (BBB) is associated with the heterogeneity of cognitive impairment (CI) in patients with WMH.
What was learned from the study?
BBB impairment, especially in the periventricular WMH region, might be a more sensitive indicator for cognitive and language dysfunction than WMH volume in patients with WMH and possibly explains the heterogeneity of cognitive performance in patients with similar WMH burden.