| Weak measurement, from any cause, risks type-II errors (i.e. false negatives) |
| Content validity limitations are an important source of PRO measurement weakness |
| We examined how MS fatigue PROs adhere to content validity standards |
| Quality has improved over time, but the fatigue PROs examined had poor content validity. One likely outcome is type-II errors in clinical trials |
| COSMIN content validity criteria need to be more specific and stringent |
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