Data from this post hoc analysis of PROMISE-2 support the use of 4 or fewer monthly headache days as a targeted treatment goal for patients with chronic migraine.

Patients who had ≤ 4 monthly headache days had a higher percentage of patient-months reporting “very much improved” and “much improved” on patient-reported outcomes.

Treatment goals should be 4 or fewer headache days per month rather than 50% reduction in monthly migraine frequency, which for patients with high migraine frequency, may still be substantial.

Having clearly articulated treatment goals will help improve communication between patients and health care providers and clarify meaningful treatment outcomes.