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Pathophysiology of seizure. Localization of key receptors that influence neuronal excitation during normal (a) and prolonged seizure conditions (b). During seizures, γ-aminobutyric acid A (GABAA) receptors are internalized, and N-methyl-d-aspartic acid (NMDA) receptors accumulate in the postsynaptic membrane, resulting in loss of inhibition and increased excitation. These changes favor self-sustaining seizures and resistance to benzodiazepines [26]
