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. 2022 Jan 13;7:13. [Version 1] doi: 10.12688/wellcomeopenres.17192.1

Table 1. steps in the REAL realist review process.

Step 1a: Locating existing
theories, development of
initial programme theory
   •   Identified 28 papers that were used to identify key causal dynamics and contextual influences on
CE, with input from scholar/practitioner experts.
   •   Initial programme theory developed at inception workshop with core team and context experts.
Step 1b: (iterative throughout)
Conceptual resources
   •   Substantive theories and concepts relevant to our programme theory were drawn on to
inform development of Context Mechanism Outcome configurations (CMOCs) – realist causal
explanations that combine into an overall programme theory.
Step 2: Searching for evidence    •   Our main search focused on malaria research trials.
   •   Potential additional searches on other health research paradigms were not conducted due to the
volume of literature available from the main search.
   •   Citation tracking and drawing on ‘sibling’ and ‘kinship’ papers identified additional papers where
our programme theory needed strengthening.
Step 3: Document selection    •   Documents were screened by BA using titles and abstracts and then by full text. 10% random
sample were reviewed by RV.
   •   Full text documents were selected based on their ability to provide relevant data for the review;
including relevant empirical detail or explanatory accounts of engagement outcomes.
Step 4: Data extraction    •   Selected documents were coded in Nvivo 12 1 .
   •   Coding frameworks were developed independently by two reviewers and iteratively refined with
input from the team.
Step 5: Data analysis and
synthesis
   •   Working across and within coded data extracts, CMOCs were iteratively developed and refined by
two reviewers with input from the wider team.
Step 6: Refine programme
theory
   •   The overall programme theory was iteratively refined and finalised with input from the review team
and content expert advisors, including at a ‘validation workshop’ towards the end of the review