Table 3.
Multivariate analysis of risk factors for osteoporosis in overall and women patients with primary biliary cholangitis
| Variables |
Overall patients (n = 268)
|
Overall patients underwent liver biopsy (n = 163)
|
Women patients (n = 236)
|
Women patients underwent liver biopsy (n = 150)
|
||||
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
|
| Age, per 10 years | 1.80 (1.33-2.44) | < 0.001 | 1.95 (1.30-2.92) | 0.001 | 1.63 (1.04-2.57) | 0.035 | 2.02 (1.27-3.20) | 0.003 |
| Fatigue | NS | NS | NS | NS | ||||
| Splenomegaly | NS | NS | 2.62 (1.18-5.80) | 0.018 | NS | |||
| Gastroesophageal varices | 2.11 (1.14-3.92) | 0.018 | NS | NS | NS | |||
| Ascites | NS | NS | NS | NS | ||||
| BMI | 0.85 (0.77-0.93) | < 0.001 | 0.87 (0.77-0.98) | 0.023 | 0.83 (0.75-0.92) | < 0.001 | 0.85 (0.74-0.97) | 0.014 |
| Previous steroid use | 4.19 (1.66-10.56) | 0.002 | NS | 4.01 (1.42-11.31) | 0.009 | 3.99 (1.24-12.87) | 0.020 | |
| Mayo risk score | 1.36 (1.08-1.71) | 0.009 | NS | 1.61 (1.22-2.14) | 0.001 | 1.64 (1.12-2.41) | 0.011 | |
| ALT | NS | NS | NS | NS | ||||
| Bilirubin | NS | 1.20 (1.01-1.42) | 0.044 | NS | NS | |||
| Albumin | NS | NS | NS | NS | ||||
| PTA | NS | NS | NS | NS | ||||
| PLT | NS | NS | NS | NS | ||||
| Postmenopausal | 2.92 (1.02-8.38) | 0.046 | NS | |||||
| Histological stage Ⅲ or Ⅳ | 3.74 (1.60-8.77) | 0.002 | 3.02 (1.13-8.06) | 0.027 | ||||
ALT: Alanine aminotransferase; BMI: Body mass index; CI: Confidence interval; NS: Not significant; OR: Odds ratio; PLT: Platelet count; PTA: Prothrombin activity.