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. 2023 Aug 23;10(8):230118. doi: 10.1098/rsos.230118

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© 2023 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — Workflow of the study. The study was divided to two parts, the early biomarkers discovery and the early intervention study. Urinary proteins at day 7 were identified by TMT labelling followed by LC-MS/MS. For the intervention study, EAE rats received intraperitoneal injection of methylprednisolone on the 9th day after modelling in the early treatment group.