Table 1.

The early dysregulated urinary proteins in EAE models.

ID	protein name	MW (kDa)	human orthologues	fold change E/N	p value	type(s)	reported in multiple sclerosis patients or animal model before
P55054	fatty acid binding protein 9	15	yes	6.17	3.32×10−2	transporter	serum [24]
P12020	cysteine-rich secretory protein 1	28	no	3.18	1.28×10−6	other
P01048	T-kininogen 1	48	yes	3.18	3.87×10−3	other	CSF [25]
Q62714	defensin RatNP-3 precursor	10	yes	2.73	1.50×10−2	other
P02764	orosomucoid 1	24	yes	2.32	4.77×10−2	other	CSF [25]
O88766	matrix metallopeptidase 8	53	yes	2.30	6.20×10−3	peptidase	tissue/plasma [26]
P01015	angiotensinogen	52	yes	2.16	2.66×10−3	growth factor	serum/CSF [27]
P20059	hemopexin	51	yes	1.82	2.29×10−3	transporter	CSF [25]
Q8VI04	asparaginase like 1	34	yes	1.78	4.00×10−2	enzyme
Q62930	complement C9	62	yes	1.73	2.27×10−3	other	CSF [25]
P08649	complement C4B	192	yes	1.66	1.08×10−2	peptidase	CSF [25]
P13635	ceruloplasmin	121	yes	1.52	7.50×10−3	enzyme	CSF [25]
Q9EQV9	carboxypeptidase B2	49	yes	1.51	1.58×10−3	peptidase	CSF [28]
P70490	milk fat globule-EGF factor 8 protein	47	yes	1.50	1.79×10−2	other
P47853	biglycan	42	yes	0.66	2.61×10−2	other
P10959	carboxylesterase 1C	60	no	0.66	1.77×10−2	enzyme
P09656	serine protease inhibitor Kazal-type 1-like	9	yes	0.65	3.35×10−2	other
P02631	oncomodulin	12	yes	0.61	2.64×10−3	other	tissue [29]
P10760	adenosylhomocysteinase	48	yes	0.60	1.85×10−2	enzyme
P11232	thioredoxin	12	yes	0.60	2.08×10−3	enzyme	serum [30]
O88989	malate dehydrogenase 1	36	yes	0.59	7.12×10−3	enzyme
Q9QZ76	myoglobin	17	yes	0.56	1.76×10−2	transporter
P10111	peptidylprolyl isomerase A	18	yes	0.56	1.77×10−2	enzyme
P07092	serpin family E member 2	44	yes	0.51	8.29×10−5	other	CSF [31]
P50116	S100 calcium binding protein A9	13	yes	0.37	1.60×10−2	other	plasma [32]