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. 2023 Aug 9;14:1225469. doi: 10.3389/fmicb.2023.1225469

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Copyright © 2023 Yang, Zhu, Zhang, Fan, Zhou, Yue, Li, Miao, Chen, Mi, Zhang, Zhang, Qian and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The efficacy of SY18ΔL60L immunization against SY18 infection. (A) Rectal temperature in the SY18ΔL60L-immunized piglets challenged with SY18. (B) Percentage of animals surviving after challenge. (C) Viral DNA levels in piglets of blood immunized with SY18ΔL60L following SY18 virus challenge. Viral DNA in oral (D,E) anal swabs from piglets immunized with SY18ΔL60L and challenged with the SY18 virus.