Table 2.

Summarizing the failure of intentionality, the corresponding brain regions, the resulting clinical syndromes, and the possible therapeutic implications.

	The aboutness aspect	The directedness aspect
Failure of Intentionality	Low sense of community, Inappropriate of an intentional object, Inappropriate of an intentional connection	Absence of intentional object, Loss of conscious access to intentional objects
Brain topography	Vestibular network, Insula, Ventral Tegmental Area, Default Mode Network	Nucleus Accumbens, Anterior Cingulate, Insula, Amygdala, Lateral Hypothalamus
Clinical manifestations	Threat, Social alienation, Delusional mood	Defeat, Entrapment, Anticipatory anxiety
Psychopathology	Psychotic Disorders, Bipolar Disorders, Psychotic Depression, Suicidal episodes	Alexithymia, Panic Disorder, Anxiety, Depression, Addiction, Suicidal ideation
Therapeutic implications	Social cohesion, Early intervention, Diet, Psychoeducation, Resilience support	Meta-emotion strategies, Mindfulness awareness meditation, Body psychotherapy, Drug policy