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Validation of hub genes. The expression of 9 hub genes were validated by dataset GSE75214. The expression levels of COL1A1, CXCL10, and MMP2 were significantly higher in CD samples and active CD samples than in HC (p < 0.01) and the FGF2 was elevated in active CD compared to HC (p< 0.1) (A–I). The expression levels of COL1A1, CXCL10, MMP2 and FGF2 were presented as a heat map (J). *p< 0. 1, ***p< 0.01, ns, no significant difference.
