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. 2023 Aug 9;14:1162786. doi: 10.3389/fendo.2023.1162786

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Copyright © 2023 Collins, Wang, Klymenko, Davis, Martinez, Zhang, So, Buechlein, Rusch, Creighton and Hawkins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The OCCC with concurrent endometriosis transcriptomic profile is molecularly distinct from benign endometrioma. (A) Multidimensional scaling (MDS) plot of transcriptomic profiles for endometrioma (Eoma, blue X’s) and ovarian clear cell carcinoma (OCCC, red X’s) with concurrent endometriosis. (B) Volcano plot representation of protein-coding transcripts overexpressed (red dots), similarly expressed (black dots), and under-expressed (green dots) in OCCC with concurrent endometriosis versus endometriomas (P_adj <0.05; Log2-Fold change<|1|. (C) Heat map representation of 5575 differentially expressed unique protein-coding gene transcripts overexpressed (red) and under-expressed (blue). Dendrogram of hierarchical clustering. Rows, protein-coding gene transcripts; columns, profiled samples.