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. 2023 Aug 9;14:1162786. doi: 10.3389/fendo.2023.1162786

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Copyright © 2023 Collins, Wang, Klymenko, Davis, Martinez, Zhang, So, Buechlein, Rusch, Creighton and Hawkins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Putative miR-10a target genes, involved in cellular proliferation and the G1/S checkpoint, are downregulated with miR-10a-5p overexpression. Cells transfected with mature miRNA mimic for miR-10a (SMOV2-10a and KK-10a) were compared to cells transfected with negative control #1 (SMOV2-10actl and KK-10actl) for each cell line. (A) SMOV2 and (B) KK gene expression panels. RQ, the relative quantity of gene of interest to ACTB, normalized to negative control #1. Expression is plotted as mean ± SEM. Each gene was run with n = 6 for each cell line and treatment group. **P< 0.001, *P< 0.05, ^† P< 0.07 using unpaired Mann-Whitney or Welch’s one-tailed t-test within cell lines.