Table 2. Cox Survival Analysis of Protein and Polygenic Risk Scores for White Participants in the Primary Event and Secondary Event Populations.
| Exposure | Covariates | Hazard ratio per SD (95% CI)a | |
|---|---|---|---|
| Primary event populationb | Secondary event populationc | ||
| Protein risk score models | |||
| No. of participants/events | 4018/465 | 6307/432 | |
| Protein risk score | Age + sex | 1.93 (1.75 to 2.13) | 1.62 (1.48 to 1.79) |
| Protein risk score | Clinical risk factorsb,c | 1.83 (1.64 to 2.04) | 1.35 (1.22 to 1.50) |
| Polygenic risk score models | |||
| No. of participants/events | 4018/465 | 6583/489 | |
| Polygenic risk score for coronary artery disease | Age + sex | 1.39 (1.26 to 1.52) | 1.08 (0.99 to 1.18) |
| Polygenic risk score for stroke | Age + sex | 1.21 (1.10 to 1.32) | 1.14 (1.04 to 1.24) |
| Both polygenic risk scores | Age + sex | ||
| Polygenic risk score for coronary artery disease | 1.36 (1.24 to 1.50) | 1.06 (0.96 to 1.16) | |
| Polygenic risk score for stroke | 1.16 (1.06 to 1.27) | 1.12 (1.03 to 1.23) | |
| Protein risk score + polygenic risk score models | |||
| No. of participants/events | 4018/465 | 3887/271 | |
| Protein risk score + polygenic risk scores | Age + sex | ||
| Protein risk score | 1.87 (1.69 to 2.07) | 1.56 (1.38-1.76) | |
| Polygenic risk score for coronary artery disease | 1.27 (1.15 to 1.39) | 1.04 (0.92-1.18) | |
| Polygenic risk score for stroke | 1.16 (1.06 to 1.28) | 1.14 (1.01-1.29) | |
| Protein risk score + polygenic risk scores | Clinical risk factorsb,c | ||
| Protein risk score | 1.79 (1.60 to 2.00) | 1.28 (1.12 to 1.46) | |
| Polygenic risk score for coronary artery disease | 1.25 (1.14 to 1.38) | 1.02 (0.90 to 1.15) | |
| Polygenic risk score for stroke | 1.16 (1.06 to 1.28) | 1.13 (1.00 to 1.28) | |
Abbreviation: SMART, secondary manifestations of arterial disease.
a
The hazard ratio is given in a standard deviation unit of the variable in the test set used. In all instances, the 95% CI for the protein risk score indicates that it is a statistically significant variable in the Cox model (significance levels are provided in eTables 5, 11, and 17 in Supplement 2).
b
In the primary event population, the clinical risk factors are age, sex, smoking, body mass index (calculated as weight in kilograms divided by height in meters squared), type 2 diabetes, hypertension treatment, and statin use.
c
The clinical risk factors correspond to the refitted SMART2 risk score using a training set in the secondary event population.