Table 1.
Published Series Reporting Survival of Children With Massive Choroidal Invasion
| Authors | Publication | Adjuvant Chemotherapy | Primary Treatment | Number of Children | Recurrence-Free Survival | Overall Survival | Follow-Up (Mo) | Comments |
|---|---|---|---|---|---|---|---|---|
| Feng et al. | (Present) | No | Enucleation, IVC or IAC | 48 | 98% | 98% | 62.1 (median) | |
| Feng et al. | (Present) | Yes | Enucleation, IVC or IAC | 12 | 58% | 67% | ||
| Kashyap et al. | Asia Pac J Clin Oncol. 2021 April;17(2):e100-e108 | NA | Enucleation | 157 | NA | 95% | NA | Included children with other concomitant high-risk features |
| Kaliki et al. | Eye (Lond). 2020 Aug;34(8):1441-1448 | 95% of high-risk RB received chemo | Enucleation | 120 | 103/120 (86%) | 103/120 (86%) | 36 (median) | Included children with other concomitant high-risk features |
| Kaliki et al. | Retina. 2018 Oct;38(10):2023-2029 | Most received chemo (>95%) | Enucleation | 69 | 64/69 (93%) | 65/69 (94%) | Indian: 28 (median) American: 49 (median) | Included children with other concomitant high-risk features |
| Kaliki et al. | Ophthalmology. 2015 Jun;122(6):1165-72 | 96% of high-risk RB received chemo | Enucleation | 69 | 66/69 (96%) | 66/69 (96%) | 28 (median) | Included children with other concomitant high-risk features |
| Bosaleh et al. | Arch Ophthalmol. 2012 Jun;130(6):724-9 | No | Enucleation or IVC | 31 | 29/31 (93%) | 30/31 (96%) | 44 (median) | Isolated massive choroidal invasion |
| Bosaleh et al. | Arch Ophthalmol. 2012 Jun;130(6):724-9 | Yes | Enucleation | 4 | 4/4 (100%) | 4/4 (100%) | ||
| Chantada et al. | JAMA Ophthalmol. 2013 Sep;131(9):1127-34 | No | NA | 33 | 94% | NA | 78 (median) | Isolated massive choroidal invasion |
| Lu et al. | Br J Ophthal. 2019 Sept;103(9)1272-1277 | Mixed | Enucleation | 31 | 27/31 (87%) | 28/31 (90%) | 60.0 (mean) | Included children with other concomitant high-risk features |
| Singh et al. | Int J Clin Oncol. 2016 Aug;21(4):651-657 | NA | Enucleation | 31 | NA | 84% | NA | Included children with other concomitant high-risk features |
| Singh et al. | Clin Exp Ophthalmol. 2015 Aug;43(6):550-7 | NA | Enucleation | 20 | NA | 80% | NA | Included children with other concomitant high-risk features |
| Suryawanshi et al. | Arch Pathol Lab Med. 2011 Aug;135(8)1017-23 | Mixed | IVC | 17 | 10/17 (59%) | NA | 24 (mean) | Included children with other concomitant high-risk features |
| Loya et al. | J AAPOS. 2023 Feb;27(1):32.e1-32.e8 | NA | NA | 10 | NA | 100% | 72.2 (mean) | Included children with massive choroidal invasion without PLONI |
| Chantada et al. | J Pediatr Hematol Oncol. 2009 May;31(5):325-9 | No | Enucleation | 10 | 9/10 (90%) | NA | 51 (median) | Isolated massive choroidal invasion |
| Yousef et al. | Turk Patoloji Derg. 2014;30(3):171-7 | Mixed | Enucleation | 9 | 9/9 (100%) | 9/9 (100% | 40 (median) | Included children with other concomitant high-risk features |
| Chévez-Barrios et al. | J Clin Oncol. 2019 Nov 1;37(31):2883-2891 | Yes | Enucleation | 6 | 5/6 (83%) | 100% | 48.0 (median) | Isolated massive choroidal invasion |
| Nawaiseh et al. | Turk Patoloji Derg. 2015;31(1):45-50 | Yes | Enucleation | 6 | 6/6 (100%) | 6/6 (100%) | 36 (median) | Included children with other concomitant high-risk features |
| Fabian et al. | Ophthalmology. 2017 Jun;124(6):851-858 | Yes | Enucleation or IVC | 5 | 5/5 (100%) | 5/5 (100%) | 73.2 (median) | One child has concomitant superficial scleral invasion |
| Laurent et al. | JAMA Ophthalmol. 2016 Dec 1;134(12):1374-1379 | No | Enucleation, IVC or IAC | 5 | 5/5 (100%) | 5/5 (100%) | NA | Isolated massive choroidal invasion |
Included series were published 2003 or later (concurrent with our study population) with minimum cohort size of 5 eyes.
NA, not applicable; PLONI, post-laminar optic nerve invasion; RB, retinoblastoma.