Table 3.
The association between categorized NLR and the incidence of irAE.
| Author | Published year | irAE type | NLR collected time | total | NLR cutoff | irAE group | Non-irAE group | ||
|---|---|---|---|---|---|---|---|---|---|
| Comparison of the categorized NLR in two groups | lower NLR | higher NLR | lower NLR | higher NLR | |||||
| Owen, Dwight H. et al. | 2018 | All types of irAE | baseline | 91 | 5 | 12 | 15 | 29 | 35 |
| Eun, Y. et al | 2019 | All types of irAE | baseline | 391 | 3 | 58 | 9 | 216 | 108 |
| Pavan, A. et al | 2019 | All types of irAE | baseline | 184 | 3 | 32 | 26 | 42 | 74 |
| Grover, S. et al | 2020 | colitis | baseline | 213 | 5 | 31 | 6 | 121 | 55 |
| Grover, S. et al | 2020 | colitis | baseline | 213 | 3 | 19 | 18 | 71 | 107 |
| Ogihara, K. et al | 2020 | ir-SAE | baseline | 78 | 3.35 | 14 | 5 | 31 | 28 |
| Peng, L. et al | 2020 | All types of irAE | baseline | 102 | 5 | 32 | 7 | 12 | 51 |
| Daniello, L. et al | 2021 | All types of irAE | baseline | 894 | 5 | 98 | 93 | 233 | 444 |
| Fan, X. et al | 2021 | All types of irAE | baseline | 111 | 5 | 25 | 5 | 69 | 12 |
| Fujimoto, A. et al | 2021 | All types of irAE | baseline | 115 | 2.86 | 25 | 20 | 20 | 50 |
| Ruan, D. Y. et al | 2021 | All types of irAE | baseline | 58 | 2.7 | 7 | 7 | 6 | 10 |
| Shi, Y. et al | 2021 | All types of irAE | baseline | 103 | 5 | 29 | 9 | 40 | 25 |
| Gannichida, A. et al | 2022 | hypothyroidism | baseline | 104 | 3.5 | 16 | 5 | 44 | 39 |
| Gannichida, A. et al | 2022 | hypothyroidism | baseline | 104 | 5 | 20 | 1 | 58 | 25 |
| Lu, X. et al | 2022 | All types of irAE | baseline | 133 | 3.56 | 12 | 10 | 56 | 55 |
| Ma, Y. et al | 2022 | All types of irAE | baseline | 95 | 8.58 | 51 | 2 | 35 | 7 |
| Matsuo, M. et al | 2022 | All types of irAE | baseline | 164 | 6.505 | 45 | 7 | 58 | 54 |
| Wu, S. et al | 2022 | cardiovascular adverse events | baseline | 495 | 3 | 42 | 22 | 176 | 255 |
| Wu, Y. L. et al | 2022 | All types of irAE | baseline | 296 | 5 | 49 | 12 | 176 | 44 |
| Extracted OR for predicting irAE in terms of categorized NLR | Variable | Extracted OR | Lower 95% CI | Higher 95% CI | |||||
| Pavan, A. et al | 2019 | All types of irAE | baseline | 184 | 3 | low vs high NLR | 1.7 | 0.8 | 3.3 |
| Grover, S. et al | 2020 | colitis | baseline | 213 | 5 | high vs low NLR | 0.34 | 0.1 | 0.9 |
| Kobayashi, Kazuo et al | 2020 | All types of irAE | baseline | 53 | 3.4 | low vs high NLR | 3.21 | 0.55 | 18.76 |
| Peng, L. et al | 2020 | All types of irAE | baseline | 102 | 5 | high vs low NLR | 0.04 | 0.01 | 0.13 |
| Egami, S. et al | 2021 | All types of irAE | 2 weeks after therapy | 171 | 4.3 | high vs low NLR | 0.57 | 0.3 | 1.08 |
| Egami, S. et al-2 | 2021 | All types of irAE | baseline | 92 | 2.3 | high vs low NLR | 5.99 | 1.73 | 20.74 |
| Fujimoto, A. et al | 2021 | All types of irAE | baseline | 115 | 2.86 | low vs high NLR | 2.69 | 1.21 | 6.01 |
| Ksienski, D. et al | 2021 | All types of irAE | baseline | 220 | 6.4 | high vs low NLR | 0.79 | 0.32 | 1.94 |
| Lee, P. Y. et al | 2021 | All types of irAE | baseline | 147 | 3 | low vs high NLR | 2.5 | 1.2 | 5.22 |
| Lee, P. Y. et al | 2021 | All types of irAE | baseline | 147 | 5 | low vs high NLR | 1.5 | 0.74 | 3.05 |
| Lin, X. et al | 2021 | grade 3-4 pneumonitis | baseline | 174 | 5.38 | high vs low NLR | 1.28 | 0.25 | 6.7 |
| Matsukane, R. et al | 2021 | All types of irAE | baseline | 275 | 3.8 | high vs low NLR | 1.18 | 0.67 | 2.06 |
| Michailidou, D. et al | 2021 | All types of irAE | baseline | 470 | 5.3 | low vs high NLR | 2.07 | 1.2 | 3.58 |
| Abed, A. et al | 2022 | All types of irAE | baseline | 179 | 5 | low vs high NLR | 1.107 | 0.511 | 2.401 |
| Cánovas, M. S. et al | 2022 | thrombosis | baseline | 665 | 4 | high vs low NLR | 2.14 | 1.24 | 3.67 |
| Cánovas, M. S. et al | 2022 | thrombosis | baseline | 665 | 3.01 | high vs low NLR | 3.65 | 1.25 | 10.62 |
| Lu, X. et al | 2022 | All types of irAE | baseline | 133 | 3.56 | high vs low NLR | 1.228 | 0.452 | 3.336 |
| Takada, S. et al | 2022 | All types of irAE | baseline | 73 | 4.3 | low vs high NLR | 0.024 | 0.0012 | 0.46 |
| Fujimoto, A. et al | 2023 | All types of irAE | baseline | 315 | 3 | low vs high NLR | 2.91 | 1.35 | 6.27 |
| Lin, X. et al | 2023 | All types of irAE | dynamic of NLR | 138 | 0.2 | change-dNLR>0.2 | 4.355 | 1.072 | 19.484 |
irAE, immune-related adverse event; NLR, neutrophil to lymphocyte ratio; OR, odd ratio; CI, confidence interval.