Table 1.
Clinical characteristics and CCTA findings
| Women N = 11 678 | Men N = 13 272 | P-value | |
|---|---|---|---|
| Leiden CCTA score, median (IQR) | 0.0 (0–5.9) | 3.9 (0–10.8) | <0.001 |
| Demographics, mean ± standard deviation | |||
| Age, years | 58.5 ± 12.4 | 55.6 ± 12.5 | <0.001 |
| BMI, kg/m2 | 27.0 ± 5.9 | 27.3 ± 4.6 | <0.001 |
| Ethnicity | <0.001 | ||
| Caucasian | 3361 (52.4) | 4276 (58.6) | |
| East Asian | 2135 (33.3) | 2296 (31.5) | |
| African | 488 (7.6) | 309 (4.2) | |
| Latin-American | 318 (5.0) | 281 (3.9) | |
| South-Asian, Middle Eastern, or other | 110 (1.7) | 133 (1.8) | |
| Cardiac symptoms, n (%) | <0.001 | ||
| No chest pain | 3041 (28.2) | 4984 (41.8) | |
| Non-anginal | 1455 (13.5) | 1441 (12.1) | |
| Atypical | 4258 (39.5) | 3878 (32.5) | |
| Typical | 2027 (18.8) | 1612 (13.5) | |
| Shortness of breath | 3926 (38.9) | 2795 (25.4) | |
| Cardiovascular risk factors, n (%) | |||
| Diabetes Mellitus | 1806 (15.6) | 1970 (15.0) | 0.192 |
| Hypertensiona | 6207 (53.6) | 6336 (48.2) | <0.001 |
| Hypercholesterolemiab | 6153 (53.0) | 6920 (52.6) | 0.481 |
| Family history for CADc | 4510 (39.2) | 4212 (32.3) | <0.001 |
| Current smoker | 1834 (15.9) | 3047 (23.2) | <0.001 |
| Cardiovascular medications, n (%) | |||
| Aspirin | 2669 (36.2) | 3684 (39.3) | <0.001 |
| Beta blocker | 2341 (31.9) | 2556 (27.7) | <0.001 |
| ACE-I/ARB | 1078 (16.9) | 1186 (15.7) | 0.051 |
| Statin | 2026 (31.7) | 2718 (33.2) | 0.060 |
Values are median and IQR, mean ± standard deviation or %.
ACE-I, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; CAD, coronary artery disease.
Blood pressure ≥ 140/90 mmHg and/or treatment with antihypertensive medication.
Total cholesterol ≥ 230 mg/dL or triglycerides ≥ 200 mg/dL and/or treatment with lipid-lowering medication.
Presence of CAD in first-degree family members at age <55 years in males and <65 years in females.