. Author manuscript; available in PMC: 2024 Apr 27.

Published in final edited form as: Methods Enzymol. 2023 Apr 27;685:171–198. doi: 10.1016/bs.mie.2023.03.013

Table 4.

Structurally characterized of bivalent ATP-allosteric EGFR inhibitors

	Name ^a	PDB ID	EGFR Kinase Domain αC-helix	Interactions with K745 and D855	Ref
1	LN3753 (2a)	6WA2	out	H-bond between imidazole and K745. H-bond between D855 and amide and K745.	(Wittlinger et al., 2022)
2	LN3754	6WAK	out	H-bond between imidazole and K745. H-bond between D855 and amide and K745.	(Wittlinger et al., 2022)
3	LN3844 (2c)	6WXN	out	H-bond between imidazole and K745. H-bond between D855 and amide and K745.	(Wittlinger et al., 2022)
4	Compound 4 (18)	3W2S	out	H-bond between urea and K745.	(Sogabe et al., 2013)

Note that we have listed all compounds according to their generic name or compound code included in the original reference. We have elected to enumerate all of the compounds here that are reported by numeral in the original reference for clarity.