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. Author manuscript; available in PMC: 2023 Nov 4.
Published in final edited form as: J Proteome Res. 2022 Sep 26;21(11):2687–2702. doi: 10.1021/acs.jproteome.2c00391

Figure 6: Maternal plasma proteomic trajectories of single-cell signatures throughout gestation.

Figure 6:

For each placental single-cell signature the average Z-score of member proteins is shown as a function of gestational age. The gene symbols corresponding to each signature are: Synciotrophoblasts (KISS1, CSH1, TFPI2, CGA, GH2, PSG3, PSG2, PSG1, HOPX, CRH, GDF15, S100P, PSG11), B cells (CD79A, CD74, RPS5), Extravillous trophoblast (AOC1, PRG2, IGF2, NOTUM, FSTL3, FLT1, EBI3, PAPPA2, HPGD, HLA-G, PAPPA, ITM2B, KRT19, SERPINE2, MFAP5, HEXB, QSOX1, TPM1, TNFSF10), Stromal 1 (TIMP1, DLK1, COL3A1, COL1A1, TGFBI, IL1RL1, COL6A2, IGFBP3, DCN, COMP, SERPINE2, COL6A1), Stromal 2 (CXCL14, EGFL6, PTGDS, APOD, TCF21, DLK1, IGFBP3, COL3A1, PLA2G2A, COL1A1, C7, GPC3, LUM, CTHRC1, SERPINF1, RARRES2), hematopoietic stem cell (SPARCL1, ENPP2, EDN1, IGFBP7, CRIP2, A2M, SOCS3, ID1), Monocytes (S100A8, LYZ, S100A9, IL1B, S100A12, CXCL2, BCL2A1, CCL3, CCL20, CXCL3, G0S2, PLAUR, FCN1, SOD2, C15orf48, EREG, IL1RN), Decidual (IGFBP1, LUM, DKK1, IGFBP2, DCN, RBP1, IGFBP4, PRL, IGFBP5, HSD11B1, IGFBP6, CD248, TIMP3, CFD), Dendritic/Macrophage 1 (APOE, APOC1, CCL18, CD74, SPP1, C1QC, FTL, RNASE1, CXCL3, CTSZ), Cytotrophoblasts (PAGE4, CGA, TINAGL1, SPINT1, SPINT2, LDHB).