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. 2023 Aug 8;8(15):e168787. doi: 10.1172/jci.insight.168787

Figure 5. RJx-01 increases muscle strength and reduces the number of denervated fibers in skeletal muscle of aged mice.

Figure 5

(A) Grip test in aged mice treated with and without RJx-01 for 18 weeks (Untreated, n = 10; RJx-01, n = 6). (B) Labeled presynaptic (neurofilament [2H3]; synaptic vesicle 2 [SV2]; green) and postsynaptic (bungarotoxin [BTX]; red) NMJ components in EDL from aged mice supplemented with and without RJx-01 for 18 weeks. Scale bar: 20 μm. At least 200 NMJs were analyzed per mouse. (C) Percentage of denervated fibers in the EDL muscle of untreated and RJx-01–treated mice (n = 3 per group). Data are shown as mean ± SEM. **P < 0.01; ***P < 0.001 by 2-tailed Student’s t test.