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. 2023 Aug 8;8(15):e170399. doi: 10.1172/jci.insight.170399

Figure 5. Subconvulsive PTZ stimulation partially mimics hyperthermic seizure effect.

Figure 5

(A) Representative traces of EEG activity following PTZ injection (30 mg/kg, i.p.) in 7 Scn1a+/RX mice. PTZ increased interictal epileptic discharges for 30 minutes without seizure in this mouse. Traces from top: right anterior, left anterior, right posterior, left posterior. (B) Raster plots of SD, seizure, and seizure+SD complex during baseline and after PTZ injection (pink shade). Two mice died during the recording. (C) The same results presented in cumulative histogram of SD, seizure, and seizure+SD incidences. (D) Quantitative comparison of frequencies of SD, seizure, seizure+SD, and total events before and after PTZ injection. n = 5; statistics calculated by paired Wilcoxon’s signed-rank test.