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. 2023 Aug 8;8(15):e167694. doi: 10.1172/jci.insight.167694

Figure 2. SRF deletion results in earlier disease onset in the SOD1 mouse model.

Figure 2

(A) Animals were analyzed weekly from 28 to 140 days of age. In each week, grip strength, NeuroScore, and body weight were determined twice, and inverted grid and pole tests were performed once. (B and C) In male mSOD1/Srf-KO mice (B) a decrease in body weight was observed earlier compared with mSOD1 mice. This was not observed in female mice (C). (D and E) The NeuroScore showed an earlier elevation in male mSOD1/Srf-KO mice compared with mSOD1 mice (D). A similar phenotype was observed in female mSOD1/Srf-KO mice (E). (F and G) The grip strength of the forelimbs was decreased in both male (F) and female (G) mSOD1/Srf-KO mice compared with mSOD1 mice starting at approximately 8 weeks. n values are indicated in B and C. Statistical testing was performed by 2-way ANOVA with Tukey corrections. *P < 0.05, **P < 0.01, ***P < 0.001.