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. 2023 Aug 8;8(15):e167694. doi: 10.1172/jci.insight.167694

Figure 3. SRF deletion results in earlier motor impairments in SOD1 mice.

Figure 3

(A and B) Male (A) and female (B) mSOD1/Srf-KO mice dropped down earlier in the inverted grid test compared with mSOD1 mice. WT and Srf-KO mice held on for 180 seconds. (C and D) In the pole test, male (C) and female (D) mSOD1/Srf-KO mice could not climb down the pole as quickly as mSOD1 mice. In contrast, WT and Srf-KO mice climbed down within 10 seconds. These data are presented as mean ± SEM. (E and F) The survival of male (E) or female (F) mSOD1/Srf-KO mice was comparable with mSOD1 mice. (G and H) The disease onset calculated on the basis of the body weight curves was earlier in male mSOD1/Srf-KO mice compared with mSOD1 mice (G). In female mice, the same tendency was observed (H). In A–D, each colored dot represents 1 mouse. n values are indicated in A and B. Statistical testing was performed by 2-way ANOVA with Tukey corrections (A–D) and Mantel-Cox test (E–H). **P < 0.01, ***P < 0.001.