Table 3.

Relevant details glyphosate NHL epidemiologic studies.

Authors	Subjects	Participation	Proxy respondents	% exposed; days glyphosate use among exposed	Exposure metric	RR	95% CI
McDuffie et al.	517 cases	Cases 67%	Cases 21%	Cases 10%	≥ 1 day/lifetime	1.2	0.8, 1.7
	1506 controls	Controls 48%	Controls 15%	Controls 9%
				Median ~ 10 days	≤ 2 days/year	1.0	0.6, 1.6
					> 2 days/year	2.1	1.3, 2.7
Hardell et al.	515 cases	Cases 91%	Cases 44%	Cases 1.6%	≥ 1 day	3.0	1.1, 8.5
	1141 controls	Controls 84%	Controls 44%	Controls 0.7%		1.9⁎	0.6, 6.2
				Unknown frequency of use, likely very few days
De Roos et al.	650 cases	91% Nebraska	Cases 31%	Cases 5.5%	≥ 1 day/lifetime	2.1⁎, !	1.1, 4.0
		89% Iowa	Controls 40%	Controls 3.2%		1.6⁎, !!	0.9, 2.8
		89% Minnesota
		96% Kansas
				< 7 days median use
	1933 controls	85% Nebraska
		78% Iowa
		78% Minnesota
		93% Kansas
Eriksson et al.	910 cases	Cases 81%	none	Cases 3%	≥ 1 day/lifetime	2.0	1.1, 3.7
	1016 controls	Controls 65%		Controls 2%		1.5⁎	0.8,2.9
				> 10 days median use	≥ 1 day/lifetime
					≤ 10 years latency	1.1	0.2, 5.1
					> 10 years latency	2.3	1.2, 4.4
					< 10 days of use	1.7	0.7, 4.1
					≥ 10 days of use	2.4	1.0, 5.4
Orsi et al.	244 cases	Cases 96%	None	Cases 5%	≥ 1 day/lifetime	1	0.5, 2.2
	436 controls	Controls 91%		Controls 6%
				Unknown frequency of use, likely very few days
Cocco et al.	2348 cases	Cases 88%	None	Cases < 1%	≥ 1 day/lifetime	3.1⁎⁎	0.6, 17.1
	2462 controls	Hospital controls 81%		Controls < 1%
		Population controls 52%
				Unknown frequency of use, likely very few days
Meloni et al.	867 cases	Cases 93%	None	Cases 2.4%	≥ 1 day/lifetime
	774 controls	Controls 62%		Controls 1.9%	High, medium, low confidence
						1.4	0.6, 2.9
				Medium & high confidence	Medium/high confidence
				Cases 1.0%		1.2	0.4, 1.5
				Control 0.8%
				Unknown frequency of use, likely very few days
Andreotti et al.	54,251 licensed pesticide applicators	Not applicable	none	83%	Intensity weighted days of use
					Quartile 1
				Median exposure 48 days	Quartile 2	0.8⁎	0.6, 1.2
					Quartile 3	0.8⁎	0.6, 1.1
				IQR 20 to 166 days	Quartile 4	0.9⁎	0.7, 1.2
						0.9⁎	0.6, 1.2
					Days of use:
					< 1 to 14 days
					14 to 38 days	0.8⁎	0.6, 1.0
					29 to 108 days	0.9⁎	0.7, 1.1
					≥ 109 days	0.9⁎	0.6, 1.1
						0.8⁎	0.6, 1.1
Leon et al.	316,210 agricultural workers	Not applicable	None	AHS 81%	≥ 1 day all subtypes	1.0^, ⁎	0.8, 1.2
				AGRICAN 37%	CLL/SLL	0.9⁎	0.7, 1.2
				NCAP 39%	FL	0.8⁎	0.5, 1.2
					MM	0.9⁎	0.7, 1.2
				Unknown frequency of glyphosate use	DLBCL	1.4⁎	1.0, 1.9

^⁎adjusted for other pesticides.

^!logistic regression estimate.

^!!hierarchical regression estimate.

^⁎⁎B-cell lymphoma.

^{^}In order: all NHL, chronic lymphocytic lymphoma/small lymphocytic lymphoma, follicular lymphoma, multiple myeloma/plasma cell leukemia, and diffuse large B-cell lymphoma.