Table 2.

Amino acid sequences of the second set of designed helical foldamers (11–18) derived from peptide 10 and their binding affinities to the RBD of the S protein.

*Positions highlighted in yellow and green indicate original mutations introduced to design peptide 10 and newly introduced mutations, respectively. Trans-(1S,2S)-2-aminocyclopentane-carboxylic acid residues are shown as black pentagons. n. a. – not active.