TABLE 1.

Comparison of Nanogels with other Nanocarriers.

Parameters	Nanogels	Liposomes	Polymeric nanoparticles	Solid lipid nanoparticles
Size	Nanoscale	Variable, typically 50–100 nm	Variable, typically 10–200 nm	Variable, typically 10–500 nm
Stability	Good	Moderate	Good	Good
Drug Loading	High	Moderate	High	High
Release Mechanism	Controlled release	Variable	Variable	Variable
Targeting Ability	Can be modified for targeting	Can be modified for targeting	Can be modified for targeting	Can be modified for targeting
Penetration	Can penetrate biological barriers	Can penetrate biological barriers	Can penetrate biological barriers	Can penetrate biological barriers
Biocompatibility	Generally biocompatible	Generally biocompatible	Generally biocompatible	Generally biocompatible
Immunogenicity	Low	Low	Low	Low
Advantages	High drug loading capacity, controlled release	Lipid bilayer mimics cell membranes, can encapsulate a	Versatile drug delivery system with tunable properties	Enhanced stability, improved drug
	ability to target specific sites	wide range of drugs	potential for surface modification	encapsulation
Disadvantages	May require additional steps for synthesis and functionalization	Batch-to-batch variability, limited drug loading ca pacity	Polymeric degradation can lead to loss of stability	May require additional steps for synthesis and functionalization