TABLE 1.

Strategies employed by the RADx-UP Testing Core to support large-scale testing for community-based research with underserved populations during the COVID-19 pandemic

No.	Strategy	Description
1	Individualize test strategies for each unique study setting and population	Adaptive and agile standardized assessment tools are needed to support the individualized testing goals of studies. Monitoring frameworks should be put in place to continuously monitor test performance and use, and testing strategies should be responsive to community feedback.
2	Make knowledge accessible and digestible	Testing and regulatory expertise needs to be disseminated to investigators in real time and through accessible methods to support study needs.
3	Build a resilient and adaptable research culture for unexpected events	Build a research culture that is flexible, resilient, and able to pivot to respond to changes in a pathogen’s epidemiology, participant recruitment, and test kit manufacturing supply.
4	Invest in capacity building to create a runway for the future	Invest in capacity building for enabling underserved populations to address future public health challenges through access to health care advancements and technologies that are community driven.