TABLE 5.

Discrepant results between heart valve 16S rRNA gene PCR/sequencing and blood culture

Discrepancy between methods	New or missed identifications by heart valve 16S rRNA gene PCR/sequencing vs blood culture (no.)
Endocarditis organism detected by blood culture but not 16S rRNA gene PCR/sequencing	Staphylococcus aureus (2), Corynebacterium amycolatum (1), Staphylococcus epidermidis (1)
Endocarditis organism detected by 16S rRNA gene PCR/sequencing but not blood culture	Cutibacterium acnes (4), Bartonella species (3), Haemophilus parainfluenzae (1), S. epidermidis (1), Streptococcus mitis group (1), Streptococcus sanguinis (1)
Microorganism not detected by 16S rRNA gene PCR/sequencing in treated infective endocarditis	Streptococcus anginosus (1), Streptococcus mutans (1)
Microorganism detected by 16S rRNA gene PCR/sequencing in treated infective endocarditis	S. aureus complex (1)