TABLE 2.
MIC ranges, MIC50 and MIC90 values, modal MICs, and GM MIC values for terbinafine, fluconazole, itraconazole, posaconazole, and voriconazole against dermatophyte clinical isolates between 2021 and 2022a
| Species | Antifungal (no. of isolates tested) | MIC/MEC range | MIC50 | MIC90 | Modal MIC | GM MIC |
|---|---|---|---|---|---|---|
| All dermatophyte isolates | Terbinafine (264) | ≤0.004 to >2 | 0.015 | >2 | 0.008 | 0.031 |
| Fluconazole (190) | 0.25 to >64 | 2 | 16 | 1 | 2.84 | |
| Itraconazole (213) | ≤0.03 to 2 | ≤0.03 | 0.125 | ≤0.03 | 0.040 | |
| Posaconazole (40) | ≤0.03 to 0.125 | ≤0.03 | 0.06 | ≤0.03 | 0.035 | |
| Voriconazole (126) | ≤0.03 to 4 | ≤0.03 | 0.125 | ≤0.03 | 0.049 | |
| Trichophyton rubrum | Terbinafine (117) | ≤0.004 to >2 | 0.008 | >2 | 0.008 | 0.029 |
| Fluconazole (68) | 0.25 to >64 | 1 | 4 | 1 | 1.28 | |
| Itraconazole (88) | ≤0.03 to 0.25 | ≤0.03 | ≤0.03 | ≤0.03 | 0.033 | |
| Posaconazole (16) | ≤0.03 to 0.06 | ≤0.03 | ≤0.03 | ≤0.03 | 0.031 | |
| Voriconazole (47) | ≤0.03 to 4 | ≤0.03 | 0.06 | ≤0.03 | 0.038 | |
| Trichophyton indotineae | Terbinafine (21) | 0.5 to >2 | >2 | >2 | >2 | >2 |
| Fluconazole (20) | 8 to >64 | 16 | >64 | 16 | 19.0 | |
| Itraconazole (21) | ≤0.03 to 0.125 | ≤0.03 | 0.125 | ≤0.03 | 0.046 | |
| Posaconazole (5) | ≤0.03 to 0.125 | |||||
| Voriconazole (4) | ≤0.03 to 1 |
a
MICs for terbinafine, itraconazole, posaconazole, and voriconazole were measured after 96 h of incubation at 35°C as the lowest concentration that resulted in at least 80% inhibition of growth compared to the drug-free growth control, while that of fluconazole was measured at 50% growth inhibition. All values are in micrograms per milliliter. MIC50, MIC90, modal MIC values, and GM MICs were not calculated for posaconazole or voriconazole against T. indotineae as the number of isolates tested was less than 10.