TABLE 3.
Amino acid changes detected at specific codons within the squalene epoxidase enzyme in 11 Trichophyton indotineae isolatesa
| Isolate no. | Terbinafine MIC | V24A | T52A | E174D | D352N | A392S | L393S | F397L | Q408L | A448T | I483V |
|---|---|---|---|---|---|---|---|---|---|---|---|
| DI23-52b | 2 | + | + | + | + | + | + | − | − | − | + |
| DI23-53 | >2 | + | + | + | + | + | − | − | + | + | + |
| DI23-54 | >2 | + | + | + | + | + | − | − | + | + | + |
| DI23-55 | >2 | + | + | + | + | + | − | + | − | + | + |
| DI23-56 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-57 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-58 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-59 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-60 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-61 | >2 | + | + | + | + | + | − | + | − | − | + |
| DI23-62 | >2 | + | + | + | + | + | − | + | − | − | + |
a
Terbinafine MICs for each isolate are also provided (all values in micrograms per milliliter). +, presence of amino acid change; −, absence of change.
b
First T. indotineae isolate received by the Fungus Testing Laboratory in 2017.