Table 2.

Causal effect of NAFLD on fracture risk using genetic variant randomization in different MR methods.

Exposure	Outcome	Method	No. of SNP	OR (95% CI)	95% CI	P
NAFLD	Fracture	IVW	5	1.0016	0.998-1.0053	0.389
		MR Egger	5	1.0057	0.9969-1.0147	0.295
		Weighted median	5	1.0012	0.9970-1.0055	0.581
		Simple mode	5	1.0029	0.9961-1.0098	0.448
		Weighted mode	5	1.0013	0.9963-1.0064	0.632
MR Egger: Cochran’s Q= 2.967, P= 0.396
IVW: Cochran’s Q= 3.965, P= 0.411
MR-Egger intercept= -0.0008, P= 0.391
MR-PRESSO global test= 0.517

No outlier was observed in the MR-PRESSO analysis in MR analysis in NAFLD and fractures. CI, confidence interval; MR, Mendelian randomization; IVW, inverse-variance weighted; NAFLD, non-alcoholic fatty liver disease.