TABLE 2.

Fixed-sites model C versus model E comparison of different spike glycoprotein domains.

Partition domain	Partition sites	Model C	Model E	ω 1	ω 2	2ΔlnL	p − value
RBM	438 to 508	−7,261.466262	−7,255.001290	0.62707	3.2743	12.93	0.001557
RBD + RBM	319 to 508	−7,297.818295	−7,269.786682	0.56590	2.200195	56.063	6.699e−13
NTD + RBD-RBM	13 to 437	−7,306.326552	−7,306.912476	0.64751	1.14141	−1.1718	1
NTD + RBD + RBM	13 to 508	−7,275.033142	−7,263.550404	0.035330	1.46900	22.965	1.031e−05
NTD	13 to 303	−7,311.588690	−7,307.785633	0.035330	1.46900	7.6061	0.0223

RBM: receptor-binding motif; RBD: receptor-binding domain; NTD = N-terminal domain.

Model C = different rs, same (κ, ω), different π s.

Model E = different rs, (κ, ω), and π s.

2ΔlnL = log-likelihood ratio test.

p − value = p − value of the chi-squared test.