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. 2023 Aug 16;2023:5513245. doi: 10.1155/2023/5513245

Figure 3.

Figure 3

Role of lnc-MRGPRF-6:1 in human monocyte-derived macrophage ferroptosis. (a) CD14 immunofluorescence staining of human monocyte. (b, c) The mRNA level of lnc-MRGPRF-6:1. (d–h, j–n) The relative expression of MDA (d, j), ROS (e, k), LDH (f, l), GSH (g, m), and SOD (h, n). (i, o) Cell viability. The data were expressed as mean with standard deviation (n = 3).  ∗∗∗∗P < 0.0001,  ∗∗∗P < 0.001,  ∗∗P < 0.01, and  ∗P < 0.05. 50 mg/L ox-LDL was used to stimulate macrophage for 24 hr. Control, negative control lentivirus-infected macrophages; KD, lnc-MRGPRF-6:1 knockdown macrophage; OV, lnc-MRGPRF-6:1 overexpression of macrophage. MDA, malondialdehyde; ROS, reactive oxygen species; LDH, lactate dehydrogenase; GSH, glutathione; SOD, superoxide dismutase.