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. 2023 Aug 3;5(8):1319–1336. doi: 10.1038/s42255-023-00839-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — RNA-seq of human primary brown and white adipocytes identified the SERT as a top DEG in brown adipocytes. We have shown that serotonin suppresses brown adipocyte thermogenesis and decreases UCP1 expression through the 5-HT_2B receptor. We have also determined that SERT functions to scavenge extracellular serotonin in human brown adipocytes, and that inhibition of SERT by SSRIs augments the suppressive effect of serotonin on BAT thermogenesis.