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. 2023 May 23;94(9):757–768. doi: 10.1136/jnnp-2022-330412

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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(A) Median (+/− IQR) fold change from baseline of sNfL in inebilizumab-treated and placebo-treated participants. Significance of changes between treatment groups assessed using Mann-Whitney U test. Boxplots of sNfL concentrations in (B) participants who did not experience RCP attacks and (C) those who did experience RCP attacks. Dashed vertical lines show when all participants received inebilizumab therapy at the end of the RCP and start of the OLP. Dashed horizontal lines show the threshold for elevated sNfL concentrations. Significance of changes from baseline in each treatment group was assessed using the Wilcoxon-signed rank test; *p<0.05; **p<0.01; ***p<0.001. FC, fold change; OLP, open-label period; RCP, randomised controlled period; sNfL, serum neurofilament light chain; W, week.