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. 2023 Feb 22;60(9):894–904. doi: 10.1136/jmg-2022-108627

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Brain atrophy pattern and gene expression overlap in study 1. (A) Atrophy pattern of case 1 compared with healthy controls. (B) Atrophy pattern of case 2 compared with HC. (C) Atrophy pattern of case 1 compared with Ng-FTD controls. (D) Atrophy pattern of case 2 compared with Ng-FTD controls. All brain areas reported reached p<0.001, uncorrected, and had an extent threshold of 50 voxels. (E) Overlap between atrophied regions in cases 1 or 2 and sites of expression of the TREM2 gene. (F Three-dimensional surface rendering and medial view of TREM2 gene expression in donor H0351.1009 (Allen Human Brain). FTD, frontotemporal dementia.